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Topiramate
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Topiramate

Topiramate is a broad spectrum, antiepileptic drug used for various types of seizures, Lennox-Gastaut syndrome (a type of childhood onset epilepsy), and migraine prophylaxis. Topiramate blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid (GABA) activity at some of the GABA receptors, and inhibits potentiation of the glutamate receptor and carbonic anhydrase enzyme, which all contribute to its antiepileptic and antimigraine efficacy.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Extended Release
  • Tablet
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Cladogenetic correlates of genomic expansions in the recent evolution of actinopterygiian fishes. Among them, two local ablative modalities, percutaneous ethanol injection and percutaneous radiofrequency ablation, have been accepted as the only potentially curative nonsurgical treatments for hepatocellular carcinoma. Studies on the mechanism of the intestinal active transport of sugars. Through RNA interference (RNAi)-based screening of serine/threonine phosphatases in Drosophila S2 cells, we identified pyruvate dehydrogenase phosphatase (PDP) to be required for dephosphorylation of Mothers against Decapentaplegic (MAD), a Drosophila Smad. Nonionizing radiant energy as an agent in altering the incidence of x-ray-induced chromatid aberrations.

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This chapter discusses recent findings on how memory T cells develop to confer long-term protective immunity. Conducting the audit was problematic because there were not pre-defined audit standards. Older patients had a higher incidence of more severe chondral grade and number of chondral injuries at the time of ACL reconstruction. In addition, 25 matched normal (MN) tissue samples were examined. The probability of an intact perineum increased in deliveries performed by midwives.

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Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin. Opposite to the effects observed in intact ganglia, excitability was greater in dissociated cutaneous nociceptors obtained from inflamed rats, although the magnitude of the IS-induced increase in excitability was not significantly affected by inflammation. Necrosis induction was accompanied by a distinct mode of caspase-3 cleavage, yielding a 29-kDa fragment. Those with erectile dysfunction should also be tested for serum 25-hydroxyvitamin D concentration.

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Stimulation of mitogenesis by the epidermal growth factor (EGF) operates through a pathway involving the receptor, the small G-protein Ras and protein kinases of the MAP kinase cascade. Combining mCherry- and GFP-tagged proteins also revealed that PspA colocalizes with PspB and PspC into large stationary foci, often located close to the pole of induced cells.

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Virus-like particles in chemically induced carcinoma of the uterine cervix. Clinical observation and laboratory examinations were performed, including erythrocyte sedimentation rate, C-reactive protein, tuberculin skin test and X-ray examination. Goats in the supplemented groups had higher total dry matter and nitrogen intakes and higher N retention and body mass gains than unsupplemented counterparts.

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The ability of an anti-lipid A monoclonal antibody (E5) to inhibit the effects of LPS was also investigated. Our study investigates the magnetic resonance imaging (MRI) appearance of the matrix-induced autologous chondrocyte implantation (MACI) graft at 5-year follow-up to determine if it provides a durable treatment option in patients with an average age of 42 (standard deviation 11.6). Continuous glucose monitoring offers a solution to the difficulties of dosing intravenous insulin properly to maintain glycemic control. Comparison of sleep parameters obtained from actigraphy and polysomnography during the rehabilitative phase after burn. In situ forming implants for periodontitis treatment with improved adhesive properties.

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Sometimes, in childbirth women, suffering from diabetes, argyrophilia of the intracellular limits is enhanced. Implanted coil costs were retrospectively obtained for all 387 consecutive aneurysm coiling procedures of saccular aneurysms performed in 342 patients over 2.5 years at the Cleveland Clinic. Effects of acupuncture hypothermia and its relationship to changes of AVP contents in the plasma and CSF in the rabbits

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This location is frequently determined by the interpretation of fluorescence microscope images. Moreover our case suggests the possibility of a positive effect of corticosteroids on such a complication, with an improvement of clinical symptoms as well as of electrophysiological results.

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The data suggest a role for EPDEN-mediated interspecies communication by inducing expression of genes for anti-inflammation cytokines, antioxidation, and activation of Wnt signaling, which are crucial for maintaining intestinal homeostasis. Vibrotactile sensibility, strength, motor performance, sensorineural symptoms and signs, and vascular symptoms in the hands, as well as mercury concentrations in biological samples and cervicobrachial symptoms, were studied. The objective of this study was to determine normal hematologic and plasma biochemical reference intervals for healthy wild Lake Sturgeon. In both Balb/c and C57/BL6 mice that received the plasmid DNA replicon vaccines derived from Semliki Forest virus (SFV) encoding the Hc gene of BoNT/A (AHc), the immunogenicity was significantly modulated and enhanced by co-delivery or co-express of the IL-4 molecular adjuvant.

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Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Latex allergen quantification was determined on both glove surfaces using an ELISA method. The addition of specific antibody to mycoplasma--macrophage cultures stimulated phagocytosis of the organisms. Laccase-catalysed functionalisation of chitosan by ferulic acid and ethyl ferulate: evaluation of physicochemical and biofunctional properties.

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To evaluate a new hydroxyapatite-coated titanium sleeve and titanium peg system for HA orbital implants. Fourier transform infrared spectroscopy applied to the Milan cathedral stone samples revealed characteristic features of biodeteriorated synthetic resins that differentiated them from the aged but nonbiodeteriorated samples. The presence of TM in these locales was ascertained by staining of cells with antibodies reacting with endogenous TMs and through the expression of hemaglutinin- and green fluorescent protein-tagged TM isoforms. We analyzed the karyotypes in 6 cases of multiple congenital abnormalities and 1 case of spontaneous abortion (case 2). A second disease is nearing eradication, with dracunculiasis cases decreasing.

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We analyse necrosis growth due to thermal coagulation induced by laser light absorption and limited by heat diffusion into the surrounding live tissue. By the end of the eighties, the dramatic improvement in the results of transplantation, the disappearance of transfusions prescribed in haemodialyzed patients after recombinant human erythropoietin became available and finally the evidence of the transfusion risk have raised questions both on transfusion policy, and even on the reality of the transfusion effect itself. The results constitute a preliminary atlas of spatiotemporal patterns of endosperm gene expression in support of future efforts for understanding the underlying mechanisms that control seed yield and quality. There were apparent discrepancies and contradictions in the studies as some reported significant association between both while others observed no significant association. Serial transmural cardiac biopsies were taken at baseline following 20 min of normothermic global ischemia (induced by crossclamping the aorta) and at 20, 40, and 60 min of reperfusion.

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The clinical significance of the test was studied in 322 patients with liver diseases. In the present study, we demonstrated that SERPINA3 expression was significantly up-regulated in EC samples and was closely correlated with lower differentiation, higher stage, positive lymph node or vascular thrombosis and negative estrogen receptor (ER), indicating a poor prognosis. The aim of the study was to determine the positive predictive value (PPV) of parathyroid scintigraphy (PS) and to some extent ultrasonography (US), defined as the probability of finding one single adenoma on the affected side at surgery when the scans had shown one single focus.

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Quantitative evaluation of autoradiograms on the basis of track or grain counting. The patient received aerosolized ribavirin, one dose of intravenous immunoglobulin, and one dose of palivizumab. The bifunctional imidoester dimethyl suberimidate hydrochloride can stabilize rat red blood cells (RBCs) by membrane protein crosslinking, and in that way they can be used as carrier systems for exogenous substances. Together, these data indicate that pIN-G is a versatile, powerful, new reporter for analysing signals controlling membrane protein trafficking, surface expression and dynamics.

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This success was very encouraging to test new compounds in combination with the DES platform. We focused on the impact of a policy change in 2004 in which the degree of experience rating was substantially increased for all firms. A case of primary cystadenocarcinoma of the appendix forming a huge mucocele In this retrospective study, we investigated the effect on survival of secondary cytoreduction for recurrent disease and variables influencing redebulking surgical outcome. Diagnostic value of the DSM and ICD categories of psychosis: an evidence-based approach.

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Identifying adolescents with metabolic syndrome (MetS) is important in China, where diabetes and MetS is highly prevalent among adults. Recent studies have shown a significant association of obesity and its complications with birth weight. MC is a rare form of prostate cancer reported in some cases to have a more aggressive clinical course than conventional adenocarcinoma (AC). Correlations for spouses, however, were not significant, suggesting a stronger influence of genes than shared environment in the determination of these traits.

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Preoperative transcatheter arterial chemoembolization of hepatoblastoma in infants. Metastatic melanoma with Schwannian differentiation in metastatic sites without lesional desmoplasia is rare and must be included in the differential diagnosis of spindled neoplasms involving lymph nodes. Our study shows the potential value of TDI indices in identifying reduced regional left ventricular systolic and diastolic longitudinal function in patients with pulmonary artery hypertension and normal left ventricular systolic function by two-dimensional transthoracic echocardiography. AF was assessed at presentation and at randomization (median 4.9 days after symptom onset).

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Potential risk factors for decline studied were: age, sex, marital status, number of medical diagnoses and medications, types of medical diagnoses, and the presence of dementia on admission to the home. Neuroprotective effect of phenylsuccinate, an inhibitor of cytosolic glutamate formation from glutamine, under anoxic conditions but not during exposure to exogenous glutamate. As mathematics remains a mystery to the majority of life scientists, we have aimed to describe our mathematical modelling strategy in biological terms.

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Evaluation of obstetrical and fetal outcomes in pregnancies complicated by acute appendicitis. Tumor staining is rare in intraorbital malignant lymphoma and is not adequate for differential diagnosis of intraorbital tumors, so biopsy is essential. Caries prevalence among 12-year-old students in Rafsanjan, Iran is less than the global standards of WHO and FDI for 2000, but close to the gold standard for 2010. The older adults had longer generation times, but there was no difference between the two groups on maintenance.

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Seventy-four healthy children were recruited to serve as controls. We have recently identified the murine glucosamine-6-phosphate (GlcN6P) acetyltransferase, EMeg32, as a developmentally regulated enzyme on the route to UDP-N:-acetylglucosamine (UDP-GlcNAc). pastoris, encoding kinases and the proteins involved in the control of growth. However, in asthma in the elderly, there are cases where physicians hesitate to introduce the inhaled corticosteroid (ICS) therapy based on the diagnosis that the use of inhalants is difficult due to the existence of a functional lesion accompanying asthma. Developmental and family centered care (DC) is a framework that aims to enhance the neurodevelopment of the infant.

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This concurrent chemoradiotherapy with PFML was safe and well tolerated. Digital imaging systems based on charge-coupled device (CCD) technologies, with pixel array size up to 2 k x 2 k at the present and increasing, are available for TEM applications and offer many attractions. Electrocardiographic modifications recorded during agony and after clinical death Inactivation of Cfc1 in mice results in laterality defects and complex cardiac malformations.

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The changes from baseline in symptoms and the incidence of BPH-related surgery and AUR were determined in men with mild (less than 8), low-moderate (8 to 12), high-moderate (13 to 19), and severe (greater than 19) baseline quasi-American Urological Association symptoms for all patients and for the subgroup with a baseline prostate-specific antigen (PSA) level of 1.4 ng/mL or greater. In bladder strips from non-diabetic animals, the presence of the urothelium resulted in marked sensitivity to carbachol-induced force generation by modulators of MaxiK and Kv7 channel activity, whereas in the diabetic animal urothelial sensitivity to these agents was significantly diminished.

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Using the GRID/VolSurf softwares, we bring evidence that when some amino acids become residues in peptides, they experience a modest increase in their polarity and a marked increase in their hydrophobicity (as assessed by their polarity field and hydrophobicity field, respectively). A very low dose of ABT-737 combined with doxorubicin synergistically enhanced sensitivity to doxorubicin-induced apoptosis in sNF96.2 cells, suggesting that ABT-737 and doxorubicin may be a good combination to effectively treat NF1-associated MPNSTs with minimal side-effects. To assess the long-term outcomes of patients with acute deep-vein thrombosis. Indications, diagnostic procedures and surgical management are discussed. Plants genetic manipulation: an approach from intellectual property.

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Renal ultrasound studies after endoscopic treatment with dextranomer/hyaluronic acid gel are unnecessary after determination of reflux resolution by voiding cystourethrography. Samples of caregiver-child interactions were coded as assertive or responsive, for type of conversational act, and for discourse level categories. Fc receptors: their diverse functions in immunity and immune disorders.

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Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risks. The perimetric-magnetic resonance imaging correlation is in exquisite agreement with recent information about the representation of the visual field in the human primary visual cortex. The impact of patient aggression on community pharmacists: a critical incident study. The general trend in all design optimization was to produce a somewhat bulky implant with a rectangular cross-section.

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Hexacyclinic acid, a Polyketide from Streptomyces with a Novel Carbon Skeleton We express our thanks to Hoechst AG (Frankfurt) for providing us with Streptomyces cellulosae (strain S 1013) and Mr. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. These subunit combinations are likely to correspond to different receptor subtypes, and may reflect the engagement of cholinergic and GABAergic neurons in distinct neuronal circuits in the basal forebrain. State-supported dental schools: financial projections and implications. These neuronal swellings resembled presynaptic elements and contained numerous 40 nm vesicles that accumulated at the site of contact with the bead.

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Further studies are necessary to establish more uniform and optimal treatments for this rare disease. We aimed to prospectively explore the strength and stability of correlations between depression and mania-type symptoms and impairment in a broad range of social adjustment roles and domains. To identify the frequency of violent commercials during the major league baseball playoffs in 1998 and to compare it with the 1996 playoffs. Hyperbaric oxygen also accelerates the regression of atherosclerotic lesions, promotes antioxidant defenses, and suppresses the proliferation of macrophages and foam cells in atherosclerotic lesions. Structural characteristics of a globular protein investigated by X-ray photoelectron spectroscopy: comparison between a legumin film and a powdered legumin.

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Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Terpenes constitute a distinct class of natural products that attract insects, defend against phytopathogenic microbes and combat human diseases. Female patients who did not live with their partner and had never been married were more likely to report a negative perception of their general health and a higher psychological distress than those who were married. Clinical symptoms responded promptly to corticosteroids to reveal severe erosive arthropathy of both wrists. Host cell ploidy underlying the fungal feeding site is a determinant clamovid pregnancy calculator of powdery mildew growth and reproduction.

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